Synthesis of monothiooxamide derivatives based on chloroacetamides of 3-aminopyridin-2(1n)-ones

On the basis of biologically active 3-aminopyridine-2(1H)-ones, authors carried out chemical modification into derivatives corresponding monothiooxamides for first time. It has been shown that 3-aminopyridin-2(1H)-oneenter transamidation reactions with hydrazine-hydrate and are further cyclized under action chloroacetyl chloride conjugated 1,3,4-thiadizole derivatives.